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Migration of cells in the fish brain: a duel between Notch and FGF

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In the body, different types of cells must constantly move and, for greater efficiency, they usually migrate in groups. To coordinate their migration, the cells must integrate various signals present in their environment but this process remains poorly understood. By studying the migration of parapineal cells into the asymmetrical brain of zebrafish, the researchers showed that Notch signaling controls cell migration via its ability to limit the activation of the FGF pathway to a few cells located preferentially at the migration front. This study was published in the journal elife.

The Genotoul TRI platform is associated with this study.

Read more (in French)