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Cell migration in the asymmetric brain of fish

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During embryogenesis or in the context of tumor invasion, cells must integrate surrounding signals to coordinate their migration, but this process remains poorly understood.

By studying the migration of a group of cells in the asymmetrical brain of zebrafish, researchers have revealed that FGF (fibroblast growth factor) signaling is activated in a few leading cells to allow the migration of all the cells. The focal activation of the FGF pathway is modulated by the asymmetric Nodal signal to orient the left-hand migration.

This study, to which the Imaging & Cytometry (TRI) platform of Genotoul is associated, is published in PNAS.

Read more (in French)