Human adipose tissue reproduced in the laboratory
Reproduce human adipose tissue in the laboratory? It is now possible thanks to a research team bringing together Inserm, CNRS, Toulouse III – Paul Sabatier University, the Blood French Establishment and the National Veterinary School of Toulouse in the StromaLab laboratory. This team has developed – through the 3-dimensional culture – small cell units that mimic the characteristics and organization of adipose tissue as it occurs in vivo: the organoids of adipose tissue or “adipospheres”. In their article in Scientific Reports, researchers detail the different steps of the experimental conditions necessary to obtain these adipospheres from human cells. This innovation could permit to study the pathologies associated with the dysfunction of this tissue such as obesity and type 2 diabetes but also to develop new drugs to treat these diseases.
The Genotoul Animal Phenotyping and TRI platforms are associated with this study.