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Single cell analysis of specialized blood vessels that mediate lymphocyte entry to lymphoid organs

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High endothelial venules (HEVs) are specialized blood vessels that play a critical role in immunity by allowing trafficking of lymphocytes through the different lymphoid organs of the body. HEVs are lined by endothelial cells with a plump almost cuboidal morphology. The team of Jean-Philippe Girard at the IPBS (CNRS/UT3 – Paul Sabatier) reports the first analysis of HEV endothelial cells by single-cell RNA sequencing and uncovers their molecular differences with endothelial cells from other blood vessels. This study was published in CELL REPORTS on March 12th 2019.

The Genotoul Imaging and Cytometry, Animal Phenotyping, Bioinformatics and GeT plateforms are associated with this study.

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